Truth Fertility

Truth Fertility

Semen Culture Testing

Standard Semen Testing Doesn't Look For Everything

Investigating bacteria and infection that may be affecting sperm health, fertility or your partner's reproductive microbiome.

Standard Semen Testing Doesn't Look For Everything

A standard semen analysis measures sperm concentration, motility and morphology.

But it doesn't routinely tell us whether potentially significant bacteria are present within the semen.

Bacterial infection or inflammation within the male reproductive tract may affect sperm quality and, in some circumstances, may also be relevant where a female partner has recurrent or persistent vaginal microbiome findings.

At Truth Fertility, we can arrange semen culture testing to investigate whether potentially significant bacteria are present and, where bacteria are identified, help determine the appropriate next steps.

What Is A Semen Culture?

A semen culture is a laboratory test that looks for microorganisms within a semen sample.

Unlike a standard semen analysis, which assesses the sperm themselves, semen culture is designed to identify bacterial growth that may indicate infection or colonisation within the male reproductive tract.

Where bacteria are cultured, antibiotic sensitivity testing is also performed where applicable, helping clinicians identify which antibiotics are likely to be effective if treatment is required.

Not every bacterium detected necessarily requires treatment. Results need to be interpreted alongside symptoms, semen quality, your partner's microbiome and your wider fertility history.

How it works

Laboratory testing is performed by The Doctors Laboratory (TDL) and arranged through our clinical partnership with IVF Matters.

1

Arrange your test

Order your semen culture through Truth Fertility. Your home collection kit will be sent directly to you, with everything you need to collect and return your sample for specialist laboratory analysis.

2

Provide your sample

Follow the collection instructions provided with your kit and return your sample to the laboratory as directed.

3

Receive your results

Your sample is analysed by The Doctors Laboratory (TDL). If potentially significant bacteria are identified, antibiotic sensitivity testing can help inform appropriate treatment where this is clinically indicated.

Why Can Bacteria In Semen Matter For Fertility?

The male reproductive tract has its own microbial environment, and research is increasingly exploring the relationship between microorganisms, inflammation and sperm health.

Certain bacterial infections have been associated with changes in semen parameters, including sperm concentration and motility, and may contribute to inflammation or oxidative stress within the male reproductive tract.

However, detecting bacteria doesn't automatically mean that they are responsible for a fertility problem.

This is why we use semen culture as a targeted investigation, rather than recommending it routinely to every man trying to conceive.

When Might We Recommend A Semen Culture?

Semen culture may be worth considering where there are:

  • Reduced or unexplained semen parameters
  • Signs of inflammation or infection within a semen analysis
  • Urinary or genital symptoms
  • Recurrent or persistent vaginal microbiome findings in a partner
  • Concerns about bacteria being shared between partners
  • Recurrent fertility problems where infection may warrant further investigation

Testing may also be considered alongside other male fertility investigations where standard results haven't provided the whole picture.

Semen Culture And The Vaginal Microbiome

Sometimes looking at one partner isn't enough.

Certain bacteria can be present within both the female and male reproductive tracts, which means that treating a vaginal microbiome imbalance without considering the male partner may not always address the complete picture.

Where particular bacteria are identified on a vaginal microbiome test, we may recommend partner treatment without further testing in some circumstances.

In others - particularly where semen parameters are reduced, symptoms are present, or there is uncertainty about what is happening within the male reproductive tract - a semen culture may provide useful additional information.

This allows us to take a couple-focused approach to the reproductive microbiome, rather than repeatedly treating one partner in isolation.

What Happens If Bacteria Are Found?

A positive culture doesn't automatically mean antibiotics are required.

The organism identified, your symptoms, semen parameters, fertility history and your partner's results all need to be considered.

Where treatment is clinically appropriate, antibiotic sensitivity testing can help guide the choice of medication.

Truth Fertility can also help coordinate further clinical assessment and prescribing where required, including considering whether both partners should be treated at the same time to reduce the risk of reinfection.

Semen Culture, Semen Analysis Or Sperm DNA Fragmentation?

These tests investigate different aspects of male fertility.

Semen Analysis

How are the sperm performing?

Measures sperm concentration, motility and morphology and is usually the starting point for assessing male fertility.

Semen Culture

Are potentially significant bacteria present?

Looks for bacterial growth within semen and can provide antibiotic sensitivity information when relevant.

Sperm DNA Fragmentation

What is the quality of the DNA carried by the sperm?

Looks beyond the conventional semen analysis to assess damage to sperm DNA, which may be relevant in unexplained infertility, recurrent miscarriage or unsuccessful fertility treatment.

Sometimes one investigation is enough. In other cases, combining tests can provide a much clearer picture of male reproductive health.

Why Test Through Truth Fertility?

✔ Targeted testing based on your fertility history

✔ Testing arranged through our clinical partners

✔ Specialist laboratory semen culture

✔ Antibiotic sensitivity testing where applicable

✔ Results considered alongside semen quality and fertility history

✔ Partner microbiome findings taken into account

✔ Access to further clinical assessment and prescribing where appropriate

Price List

Semen Culture Test

£89

Arrange A Semen Culture

If you'd like to arrange semen culture testing, or you're unsure whether semen culture, semen analysis or sperm DNA fragmentation testing would be most appropriate, simply get in touch and we'll help you decide on the most useful next step.