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Trusted Sperm DNA Fragmentation Testing by Examen

We have used Examen’s Sperm DNA Fragmentation (SDF) tests since 2019 because they are the most accurate SDF tests commercially available and are used by over 80% of the top fertility clinics in the UK & Ireland.

Book Sample Drop-Off

Examen Hub Sample Drop-Off

We provide a sperm DNA fragmentation testing service at the following locations

Bristol Clinic

Bristol Osteopaths

BS1 4HQ

Map

Bristol Test Day

Monday 15th June

Drop-off window: 11:30-12:00

Frome Clinic

Frome Therapy Rooms

BA11 1BH

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Frome Test Day

Saturday 13th June

Drop-off window: 17:30-18:00

How the test works

1

Book Your Test

Reserve your place online with a £115 deposit. We’ll then arrange delivery of your sample collection kit and confirm the most appropriate test level with you.

2

Collect Your Sample at Home

Produce your sample in the privacy of your own home and bring it to the clinic within 45 minutes of production.

3

Laboratory Analysis & Results

Your sample is analysed by Examen’s specialist laboratory using the Comet assay. Results will be shared with you once available, and interpretation can be arranged if required.

Ready to book?

Appointments can now be booked online. Your appointment time simply helps us manage the number of samples arriving that day. Please aim to arrive within the drop-off window provided in your instructions rather than exactly at your appointment time.

A £115 deposit secures your place, which will be deducted from the total cost of your test.

All tests (Exact, Extend, Extensiv) are booked using the same sample drop-off appointment. The most appropriate test level can be confirmed after booking.

Once your booking is confirmed, we will send your sample collection kit and instructions.

Samples are produced at home for privacy and brought to the clinic within 45 minutes.

If you have any questions about sample collection or logistics, we’re very happy to talk you through it — just get in touch.

Why the type of DNA damage matters

Recent multi-centre research published in Human Reproduction found that double-stranded sperm DNA damage is independently associated with lower IVF live birth rates.

In this study of over 300 IVF cycles:

  • Each 1% increase in double-strand DNA damage was associated with a 16% reduction in the odds of live birth
  • Higher levels of damage were linked to poorer outcomes, particularly as female age increased

This is important because many standard DNA fragmentation tests do not distinguish between types of DNA damage.

At Truth Fertility, we use the Comet assay, which allows us to assess double-strand damage directly.

Not sure if you need this test?

We have a wealth of resources to help you understand whether Sperm DNA Fragmentation could be affecting your ability to conceive.

If you have had any of the following then a sperm DNA fragmentation test should be considered:

  • Recurrent miscarriages or chemical pregnancies.
  • Ectopic pregnancy.
  • Inability to conceive or a diagnosis of 'unexplained infertility'.
  • Embryos that fail to develop 72 hours after fertilisation.
  • Morphology (normal forms) of 4% or below.
  • Varicocele (varicosed veins in or around the scrotum)


For more information please read Examen's patient brochure.

Read Brochure

Our Clinical Outcomes

Improved with personalised advice

67%

After structured fertility guidance

Average reduction observed

−6.5%

Across repeat DNA fragmentation tests

Improved with acupuncture added

80%

When acupuncture was included

Average reduction with acupuncture

−7.4%

In combined treatment group

No improvement observed

25%

Showed little change or an increase

These figures come from anonymised repeat sperm DNA fragmentation tests in men who received structured fertility guidance through our clinics, with some also undergoing acupuncture treatment. Individual outcomes vary.
View Clinical Audit

Hidden Sperm Damage: Could It Be DNA Fragmentation?

Unexplained infertility can be frustrating, especially when test results seem normal. Our featured article sheds light on sperm DNA fragmentation — microscopic breaks in sperm DNA that can reduce fertility, increase miscarriage risk, and go unnoticed without advanced testing.

Sperm DNA Fragmentation: Miscarriage, IVF Failure & Testing

Featured Post

Sperm DNA Fragmentation: Miscarriage, IVF Failure & Testing

Sperm DNA fragmentation may underlie unexplained infertility or recurrent miscarriage by impairing embryo and placenta development.

Read more

Which test is right for you?

  • Exact (Single Strand)
    Initial screening where oxidative stress is suspected
  • Extend (Double Strand)
    Deeper assessment in cases of miscarriage or IVF failure
  • Extensiv (Combined)
    Most comprehensive option for a complete picture before treatment

If unsure, most patients choose Extensiv to avoid missing clinically relevant damage.

Price List

The Exact Test

A global assessment of sperm DNA fragmentation, measuring overall levels of DNA damage across the sample. This includes both single- and double-strand damage but does not distinguish between them.

Standalone test£545
Existing Truth Fertility patient rate£495
Book Sample Drop-Off

The Extend Test

A specialist test focusing specifically on double-strand DNA damage — the type of damage more strongly associated with poor embryo development, miscarriage, and reduced IVF success.

Standalone test£670
Existing Truth Fertility patient rate£620
Book Sample Drop-Off

The Extensiv Test

A combined assessment measuring both overall DNA fragmentation and double-strand DNA damage. This provides a more complete picture of both the amount and type of DNA damage present.

Standalone test£970
Existing Truth Fertility patient rate£920
Book Sample Drop-Off

Get in touch for more help