Truth Fertility

Truth Fertility

Diagnostics · Unexplained infertility

Unexplained Infertility Testing

When standard tests come back normal, it can be hard to know what to do next. Here's what's usually checked, what often isn't, and which further investigations might be worth considering.

What does "unexplained infertility" mean?

Unexplained infertility is the diagnosis given when you haven't conceived after a year or more of trying, but standard investigations haven't found a clear cause. It's common, and it's thought to affect around a quarter of couples who go through fertility investigations.

Standard NHS investigations usually cover:

  • Ovulation, usually checked with a progesterone blood test in the second half of your cycle
  • Whether the fallopian tubes are open
  • A semen analysis

Those are the right places to start. But they don't look at everything, and a "normal" result isn't always the whole picture. That doesn't mean everyone needs more tests. It means it's worth asking which gaps might matter in your situation.

Investigations that may be worth considering

These are the gaps we most often look at when standard tests have come back normal. Which ones matter depends on your history, so we wouldn't expect anyone to need all of them.

Situational
Emerging
  • Sperm DNA fragmentationfrom £545
    Situational

    Male factors are involved in around half of couples' fertility difficulties, and a standard semen analysis can't detect DNA damage in sperm. It's one of the tests we most often discuss when everything else looks normal.

    About this test →
  • Female hormones and ovarian reserve (including AMH)Via consultation
    Situational

    Hormone tests timed to your cycle can give a clearer picture of ovulation and egg reserve. It's worth knowing that AMH on its own doesn't predict your chance of conceiving naturally.

    About this test →
  • Thyroid function and antibodiesVia consultation
    Situational

    Even mild thyroid problems can affect ovulation and early pregnancy. Thyroid antibodies aren't always included in standard testing.

    About this test →
  • Comprehensive iron panelVia consultation
    Situational

    Low iron stores are common in women of reproductive age and can be missed when only haemoglobin is checked. A full iron panel gives a more complete picture.

    About this test →
  • Vaginal microbiome£325
    Emerging

    Some studies have linked an imbalance in vaginal bacteria with lower chances of conception and implantation. It's an emerging area rather than a routine test, and we'll be clear about what a result can tell you.

    About this test →
  • Continuous glucose monitoring£300
    Emerging

    Insulin resistance can affect ovulation and egg quality, even when standard blood tests look fine. It's more likely to be relevant if you have PCOS, a family history of diabetes or other signs.

    About this test →

Tests you might hear about

Not routinely recommended

Endometrial receptivity testing (ERA)

Some IVF clinics offer tests to time embryo transfer to the lining of the womb. Randomised trials so far haven't shown that they improve live birth rates for most people, so we don't routinely recommend them.

Not recommended outside research

NK cell testing

Tests for natural killer cells and other immune markers are sometimes offered after unexplained infertility or failed IVF. Current UK and European guidelines don't recommend them outside research, as there's no good evidence that treating the results helps.

What the evidence says →

How we can help

We start by looking at everything you've already had done, so you don't repeat tests unnecessarily. From there we'll suggest the investigations most likely to be useful for you, explain what the results can and can't tell you, and help you decide what to do next, whether that's treatment with us, a question to take back to your clinic or simply more time.

Talk it through with us

If you'd like a full review of your history and results, an initial consultation is the best place to start.

Most patients start here

Fertility initial consultation

£180

60 minutes. A full review of your case and existing tests, which diagnostics might be missing, and a personalised plan.

Not sure where to start?

Check with Verity First

£35

Send a short account of your journey and your existing results, and Verity will suggest the most useful next step. It's a brief review rather than a full treatment plan, and the £35 can be credited towards a later consultation or acupuncture appointment.